Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

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作者： Maria Cid, Jose ^[1] ; Tresadern, Gary ^[2] ; Antonio Vega, Juan ^[2] ; Isabel de Lucas, Ana ^[3] ; del Cerro, Alcira ^[1] ; Matesanz, Encamacion ^[2] ; Lourdes Linares, Maria ^[1] ; Garcia, Aranzazu ^[1] ; Ituttrino, Laura ^[2] ; Perez-Benito, Laura ^[1] ; Macdonald, Gregor J. ^[2] ; Oehlrich, Daniel ^[1] ; Lavreysen, Hilde ^[1] ; Peeters, Luc ^[2] ; Ceusters, Marc ^[2] ; Ahnaou, Abdellah ^[2] ; Drinkenburg, Wilhelmus ^[2] ; Mackie, Claire ^[1] ; Somers, Marijke ^[1] ; Trabanco, Andres A. ^[1]

作者单位： Janssen Res & Dev, Toledo 45007, Spain ^[1] Janssen Pharmaceut NV, Janssen Res & Dev, B-2340 Beerse, Belgium ^[2] Univ Autonoma Barcelona, Fac Med, Lab Med Computac Unitat Bioestadist, Bellaterra 08193, Spain ^[3]

发布时间 2017-04-06

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Journal of Medicinal Chemistry

2016年59卷18期

8495-8507页

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Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

Journal of Medicinal Chemistry

相似文献

Journal of Medicinal Chemistry

相关期刊

检索历史清除