Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2- phenylbutyl)aziridines and evaluation of their antimalarial activity

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作者： D'Hooghe,M. ^[1] ; Vervisch,K. ^[2] ; T?rnroos,K.W. ^[3] ; Verhaeghe,T. ^[4] ; Desmet,T. ^[5] ; Lategan,C. ; Smith,P.J. ; Chibale,K. ; DeKimpe,N.

作者单位： Department of Chemistry, University of Bergen, Allégt 41, 5007 Bergen, Norway ^[1] Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering ^[2] Medical School, University of Cape Town, Groote Schuur Hospital, Cape Town, K45 OMB, Observatory ^[3] Department of Chemistry, Institute of Infectious Disease and Molecular Medicine, University of Cape ^[4] Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent ^[5]

关键词 1-Azabicyclo[2.2.1]heptanes Antimalarial agents Aziridines Ligand docking Plasmepsin II Ring transformation

发布时间 2018-07-27

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