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Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods

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第一作者： Jingtao Lu

作者： Jingtao Lu ^[1] ; Jianguo Li ; Gabriel Helmlinger ; Nidal Al-Huniti

作者单位： Quantitative Clinical Pharmacology, IMED Biotech Unit, AstraZeneca Pharmaceuticals ^[1]

关键词 QTc interval prolongation C-?QTcF modeling Linear mixed-effects model Linear quantile mixed model Single-ascending dose study Multiple-ascending dose study Thorough QT/QTc study AZD5672

发布时间 2019-02-18

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Journal of pharmacokinetics and pharmacodynamics

2018年45卷3期

469-482页

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Journal of pharmacokinetics and pharmacodynamics

2018年45卷3期

469-482页

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Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods

Journal of pharmacokinetics and pharmacodynamics

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Journal of pharmacokinetics and pharmacodynamics

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Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods

Journal of pharmacokinetics and pharmacodynamics

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Journal of pharmacokinetics and pharmacodynamics

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