The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

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作者： Kolbinger, Fiona R. ^[1] ; Koeneke, Emily ^[2] ; Ridinger, Johannes ^[3] ; Heimburg, Tino ^[4] ; Mueller, Michael ^[5] ; Bayer, Theresa ; Sippl, Wolfgang ; Jung, Manfred ; Gunkel, Nikolas ; Miller, Aubry K. ; Westermann, Frank ; Witt, Olaf ; Oehme, Ina

作者单位： NCT Heidelberg KiTZ, Hopp Childrens Canc Ctr, Preclin Program, D-69120 Heidelberg, Germany ^[1] German Canc Res Ctr, Canc Drug Dev Grp, Neuenheimer Feld 580, D-69120 Heidelberg, Germany ^[2] Martin Luther Univ Halle Wittenberg, Inst Pharm, Dept Med Chem, W Langenbeck Str 4, D-06120 Halle ^[3] German Canc Res Ctr, Res Grp Neuroblastoma Genom, Neuenheimer Feld 280, D-69120 Heidelberg, Germany ^[4] Albert Ludwigs Univ Freiburg, Inst Pharmaceut Sci, Albertstr 25, D-79104 Freiburg, Germany ^[5]

关键词 Selective histone deacetylase inhibitor HDAC8 HDAC10 DNA repair Differentiation Targeted therapy

发布时间 2019-01-14

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