Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications

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作者： Blech, Michaela ^[1] ; Seeliger, Daniel ^[2] ; Kistler, Barbara ^[3] ; Bauer, Margit M. T. ^[4] ; Hafner, Mathias ^[5] ; Hoerer, Stefan ; Zeeb, Markus ; Nar, Herbert ; Park, John E.

作者单位： Department of Lead Identification and Optimization Support, Structural Research Group, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach, Germany ^[1] Department of Lead Identification and Optimization Support, Computational Chemistry Group, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach, Germany ^[2] Department of NBE Discovery, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach, Germany ^[3] Department of Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach, Germany ^[4] Institut für Medizintechnologie der Ruprecht-Karls-Universit?t Heidelberg & Hochschule Mannheim, Heidelberg and Mannheim, Germany ^[5]

关键词 autoantibody epitope mapping Fas fragment granulocyte/macrophage colony-stimulating factor (GM-CSF)microscale thermophoresis (MST)pulmonary alveolar proteinosis (PAP)

发布时间 2013-12-29

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