Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

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作者： Marion Lanier ^[1] ; Jason Pickens ; Simone V. Bigi ; Erica L. Bradshaw-Pierce ; Alison Chambers ; Zacharia S. Cheruvallath ; Derek Cole ; Douglas R. Dougan ; Jacques Ermolieff ; Tony Gibson ; Petro Halkowycz ; Aki Hirokawa ; Anthony Ivetac ; Joanne Miura ; Evan Nunez ; Mark Sabat ; John Tyhonas ; Haixia Wang ; Xiaolun Wang ; Steve Swann

作者单位： Departments of Medicinal Chemistry, Drug Metabolism Pharmacokinetics, Structural Biology, and Discovery Biology, Gastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, 10410 Science Center Drive, San Diego, California 92121, United States ^[1]

关键词 Apoptosis signal-regulating kinase 1 (ASK1)cardiac injury structure-based drug design (SBDD)

发布时间 2019-05-01

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