Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine

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作者： O'Neill, PM ^[1] ; Shone, AE ^[2] ; Stanford, D ^[3] ; Nixon, G ^[4] ; Asadollahy, E ^[5] ; Park, BK ^[6] ; Maggs, JL ; Roberts, P ; Stocks, PA ; Biagini, G ; Bray, PG ; Davies, J ; Berry, N ; Hall, C ; Rimmer, K ; Winstanley, PA ; Hindley, S ; Bambal, RB ; Davis, CB ; Bates, M ; Gresham, SL

作者单位： GlaxoSmithKline Inc, Med Res Ctr, Stevenage SG1 2NY, Herts, England. ^[1] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. ^[2] GlaxoSmithKline Inc, Safety Assessment, Welwyn Garden City AL6 9AR, Herts, England. ^[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England. ^[4] Univ Liverpool, Sch Biomed Sci, Dept Pharmacol & Therapeut, MRC Ctr Drug Safety Sci, Liverpool L69 3GE, Merseyside, England. ^[5] GlaxoSmithKline Drug Discovery, Drug Metab & Pharmacokinet, Collegeville, PA 19426 USA. ^[6]

关键词 DRUG-RESISTANT MALARIA PLASMODIUM-FALCIPARUM IN-VITRO DIHYDROARTEMISININ-PIPERAQUINE INDUCED AGRANULOCYTOSIS FERRIPROTOPORPHYRIN-IX CHLOROQUINE RESISTANCE HEMOGLOBIN DEGRADATION HEME CRYSTALLIZATION HEMATIN

发布时间 2013-11-20

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