Elucidating an Amorphous Form Stabilization Mechanism for Tenapanor Hydrochloride: Crystal Structure Analysis Using X-ray Diffraction, NMR Crystallography, and Molecular Modeling

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作者： Sten O. NilssonLill ^[1] ; Cory M. Widdifield ^[2] ; Anna Pettersen ^[3] ; Anna Svensk Ankarberg ^[4] ; Maria Lindkvist ^[5] ; Peter Aldred ; Sandra Gracin ; Norman Shankland ; Kenneth Shankland ; Staffan Schantz ; Lyndon Emsley

作者单位： CrystallografX Ltd, 2 Stewart Street, Milngavie, Glasgow G62 6BW, United Kingdom ^[1] Institut des Sciences Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH ^[2] Institut des Sciences Analytiques (CNRS/ENS de Lyon/UCB Lyon 1), Centre de RMN à Très Hauts Champs ^[3] Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, SE ^[4] Pharmaceutical Technology & Development, AstraZeneca Gothenburg, SE-431 83, M?lndal, Sweden ^[5]

关键词 amorphous crystal structure density functional theory solid-state NMR stabilization X-ray diffraction

发布时间 2020-11-27

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