Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up-论文-万方医学网

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Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

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第一作者： Tsuchitani, Toshiaki

作者： Tsuchitani, Toshiaki ^[1] ; Akiyoshi, Takeshi ; Imaoka, Ayuko ; Ohtani, Hisakazu

作者单位： Fac Pharm,Keio Univ ^[1]

关键词 in vitro-to-in vivo extrapolation CAT model simulation drug absorption permeability PERMEABILITY PREDICTION MONOLAYERS TRANSPORT PERFUSION RAT THICKNESS VOLUMES PAMPA LAYER

发布时间 2022-09-30

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Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

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Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

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