首页> Journal of Medicinal Chemistry> Synthesis and Pharmacological Characterization of C4(beta)-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist

Synthesis and Pharmacological Characterization of C4(beta)-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist

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作者： Monn, James A. ^[1] ; Henry, Steven S. ^[2] ; Massey, Steven M. ^[3] ; Clawson, David K. ^[4] ; Chen, Qi ^[3] ; Diseroad, Benjamin A. ^[5] ; Bhardwaj, Rajni M. ^[5] ; Atwel, Shane ^[1] ; Lu, Frances ^[5] ; Wang, Jing ^[2] ; Russell, Marijane ^[1] ; Heinz, Beverly A. ^[4] ; Wang, Xu-shan ^[1] ; Carter, Joan H. ^[3] ; Getman, Brian G. ^[1] ; Adragni, Kofi ^[5] ; Broad, Lisa M. ^[5] ; Sanger, Helene E. ^[3] ; Ursu, Daniel ^[5] ; Catlow, John T. ^[6] ; Swanson, Steven ^[4] ; Johnson, Bryan G. ^[6] ; Shaw, David B. ^[4] ; McKinzie, David L. ^[7] ; Hao, Junliang ^[3]

作者单位： Eli Lilly & Co, Discovery Chem Res & Technol, Indianapolis, IN 46285 USA ^[1] Eli Lilly & Co, Drug Disposit, Indianapolis, IN 46285 USA ^[2] Eli Lilly & Co, Struct Biol, Indianapolis, IN 46285 USA ^[3] Eli Lilly & Co, Quantitat Biol, Indianapolis, IN 46285 USA ^[4] Eli Lilly & Co, Neurosci Res, Indianapolis, IN 46285 USA ^[5] Eli Lilly & Co, Small Mol Design & Dev, Indianapolis, IN 46285 USA ^[6] Eli Lilly & Co, Stat, Indianapolis, IN 46285 USA ^[7]

发布时间 2020-06-12

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