Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates

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作者： Staben, Leanna R. ^[1] ; Chen, Jinhua ^[2] ; dela Cruz-Chuh, Josefa ; del Rosario, Geoff ; Go, Mary Ann ; Guo, Jun ; Khojasteh, S. Cyrus ; Kozak, Katherine R. ; Li, Guangmin ; Ng, Carl ; Phillips, Gail D. Lewis ; Pillow, Thomas H. ; Rowntree, Rebecca K. ; Wai, John ; Wei, BinQing ; Xu, Keyang ; Xu, Zijin ; Yu, Shang-Fan ; Zhang, Donglu ; Dragovich, Peter S.

作者单位： WuXi AppTec Co Ltd, Shanghai 200131, Peoples R China ^[1] Genentech Inc, San Francisco, CA 94080 USA ^[2]

发布时间 2021-09-26

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Journal of Medicinal Chemistry

2020年63卷17期

9603-9622页

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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates

Journal of Medicinal Chemistry

相似文献

Journal of Medicinal Chemistry

相关期刊

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