Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

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作者： Giuliano, Sandy ^[1] ; Cormerais, Yann ^[2] ; Dufies, Maeva ^[3] ; Grepin, Renaud ^[4] ; Colosetti, Pascal ^[5] ; Belaid, Amine ^[6] ; Parola, Julien ; Martin, Anthony ; Lacas-Gervais, Sandra ; Mazure, Nathalie M. ; Benhida, Rachid ; Auberger, Patrick ; Mograbi, Baharia ; Pages, Gilles

作者单位： Univ Nice Sophia Antipolis, Inst Res Canc & Aging Nice, CNRS, UMR 7284,INSERM, F-06189 Nice, France ^[1] Univ Nice Sophia Antipolis, Inst Chim Nice, CNRS, UMR 7272, F-06189 Nice, France ^[2] Ctr Antoine Lacassagne, Nice, France ^[3] Univ Nice Sophia Antipolis, Ctr Mediterraneen Med Mol, INSERM, F-06189 Nice, France ^[4] Univ Nice Sophia Antipolis, Ctr Microscopie Appl, F-06189 Nice, France ^[5] Ctr Sci Monaco, Biomed Dept, Monaco, Monaco ^[6]

关键词 angiogenesis elacridar Leu-Leu-O-Methyl lysosome proteasome inhibitors renal cell carcinoma resistance sunitinib

发布时间 2019-06-19

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