Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways

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作者： Shao ZY ^[1] ; Blodgett JAV ^[2] ; Circello BT ^[3] ; Eliot AC ^[4] ; Woodyer R ^[5] ; Li GY ^[6] ; van der Donk WA ^[7] ; Metcalf WW ^[8] ; Zhao HM

作者单位： Harvard Univ, Dept Biol Chem, Sch Med, Boston, MA 02115 USA ^[1] Dupont Cent Res & Dev, Wilmington, DE 19880 USA ^[2] Shanghai Chemspec Corp, Dept R&D, Shanghai 200333, Peoples R China ^[3] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA ^[4] Harvard Univ, Dept Mol Pharmacol, Sch Med, Boston, MA 02115 USA ^[5] Univ Illinois, Dept Biomol Engn, Urbana, IL 61801 USA ^[6] Univ Illinois, Dept Chem, Urbana, IL 61801 USA ^[7] zuChem Inc, Peoria, IL 61604 USA ^[8]

关键词 C-P BOND PHOSPHINOTHRICIN-TRIPEPTIDE SACCHAROMYCES-CEREVISIAE ALCOHOL-DEHYDROGENASE ESCHERICHIA-COLI NATURAL-PRODUCTS GENE-CLUSTER FOSFOMYCIN MECHANISM PHOSPHONOACETALDEHYDE

发布时间 2013-11-20

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