作者单位:Human Development and Health Faculty of Medicine University of Southampton[1]NIHR Southampton Biomedical Research Centre University Hospitals Southampton NHS Foundation Trust[2]Child Health University of Aberdeen[3]Centre for Genetics and Genomics Versus Arthritis Division of Musculoskeletal and Dermatological[4]National Heart and Lung Institute Imperial College London[5]Division of Infection Immunity and Respiratory Medicine School of Biological Sciences The[6]MRC Integrative Epidemiology Unit Department of Population Health Sciences Bristol Medical School[7]