Metabolism and clinical pharmacokinetics of 2-methyl-n-(2 '(pyrrolidinyl-1-ylsulfonyl)-n-[1,1 '-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools

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作者： Basak, Aarti Sawant ^[1] ; Byon, Wonkyung ; Tseng-Lovering, Elaine ; Funk, Carrie ; Wood, Linda ; Lin, Chang ; Delnomdedieu, Marielle ; Verhoest, Patrick ; Parikh, Vinod ; Cox, Loretta M. ; Miller, Emily ; Gao, Hongying ; Obach, Ronald S.

作者单位： Pfizer Inc, Dept Pharmacokinet Dynam & Metab, Cambridge, MA 02139 USA ^[1]

关键词 Clinical pharmacokinetics CYP3A5 genotype human hepatocytes metabolism monoamine oxidase phenotype polymorphism

发布时间 2019-07-25

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2014年44卷1/12期

438-454页

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Metabolism and clinical pharmacokinetics of 2-methyl-n-(2 '(pyrrolidinyl-1-ylsulfonyl)-n-[1,1 '-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools

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Metabolism and clinical pharmacokinetics of 2-methyl-n-(2 '(pyrrolidinyl-1-ylsulfonyl)-n-[1,1 '-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools

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