Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

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作者： Sturm, Gabriel ^[1] ; Cardenas, Andres ^[2] ; Bind, Marie-Abele ^[3] ; Horvath, Steve ^[4] ; Wang, Shuang ^[5] ; Wang, Yunzhang ^[6] ; Hagg, Sara ^[7] ; Hirano, Michio ; Picard, Martin

作者单位： Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden ^[1] Columbia Univ, Med Ctr, Dept Biostat, Mailman Sch Publ Hlth, New York, NY 10032 USA ^[2] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA ^[3] Harvard Univ, Dept Stat, Cambridge, MA 02138 USA ^[4] Univ Calif Los Angeles, David Geffen Sch Med, Human Genet, Los Angeles, CA 90095 USA ^[5] Columbia Univ, H Houston Merritt Ctr, Dept Neurol, Columbia Translat Neurosci Initiat,Irving Med ^[6] Columbia Univ, Dept Psychiat, Div Behav Med, Irving Med Ctr, New York, NY 10032 USA ^[7]

关键词 Aging DNA methylation epigenetic age primary culture lifespan accelerated aging

发布时间 2020-02-26

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