Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage-论文-万方医学网

Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage

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作者： Deng, Haibin ^[1] ; Gao, Yanyun ^[2] ; Trappetti, Verdiana ^[3] ; Hertig, Damian ^[4] ; Karatkevich, Darya ; Losmanova, Tereza ; Urzi, Christian ; Ge, Huixiang ; Geest, Gerrit Adriaan ; Bruggmann, Remy ; Djonov, Valentin ; Nuoffer, Jean-Marc ; Vermathen, Peter ; Zamboni, Nicola ; Riether, Carsten ; Ochsenbein, Adrian ; Peng, Ren-Wang ; Kocher, Gregor Jan ; Schmid, Ralph Alexander ; Dorn, Patrick ; Marti, Thomas Michael

作者单位： Bern Univ Hosp ^[1] Univ Bern ^[2] Translat Imaging Ctr TIC ^[3] Swiss Fed Inst Technol ^[4]

关键词 Lung cancer Cancer stem cells Tumorigenicity Mitochondrial metabolism Cellular plasticity Mitochondrial DNA Nucleotide metabolism STEM-CELLS GLYCINE DECARBOXYLASE MOUSE MODELS RESISTANCE C-13 IDENTIFICATION RESPIRATION POPULATIONS EXPRESSION AUTOPHAGY

发布时间 2022-11-15

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