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Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors

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第一作者： Verkhivker, Gennady M.

作者： Verkhivker, Gennady M. ^[1]

作者单位： Chapman Univ, Fac Phys Computat Sci & Engn, Schmid Coll Sci & Technol, Dept Computat Sci, Orange ^[1]

关键词 ErbB kinases BRAF kinases dimerization-induced kinase activation BRAF paradoxical activation allosteric regulation allosteric kinase inhibitors computational modeling of protein kinases multiscale simulations kinase residue interaction networks

发布时间 2020-06-19

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Current medicinal chemistry

2017年24卷40期

4838-4872页

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Current medicinal chemistry

2017年24卷40期

4838-4872页

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Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors

Current medicinal chemistry

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Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors

Current medicinal chemistry

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Current medicinal chemistry

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