Quantitative HLA‐class‐II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A

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作者： Diego Vincent P. ^[1] ; Luu Bernadette W. ^[2] ; Hofmann Marco ^[3] ; Dinh Long V. ^[4] ; Almeida Marcio ^[5] ; Powell Jerry S. ^[6] ; Rajalingam Raja ^[7] ; Peralta Juan M. ^[8] ; Kumar Satish ^[9] ; Curran Joanne E. ^[10] ; Sauna Zuben E. ^[11] ; Kellerman Roberta ; Park Yara ; Key Nigel S. ; Escobar Miguel A. ; Huynh Huy ; Verhagen Anne M. ; Williams‐Blangero Sarah ; Lehmann Paul V. ; Maraskovsky Eugene ; Blangero John ; Howard Tom E.

作者单位： Division of HematologyUniversity of North Carolina at Chapel HillNorth Carolina ^[1] Department of PathologyCase Western Reserve University School of MedicineCleveland,Ohio ^[2] Immunogenetics and Transplantation LaboratoryUniversity of California at San FranciscoCalifornia ^[3] Division of HematologyUniversity of Texas Health Sciences Center at HoustonTexas ^[4] South Texas Diabetes and Obesity InstituteUniversity of Texas Rio Grande ValleyBrownsville,Texas ^[5] Department of Laboratory Medicine and PathologyUniversity of North Carolina at Chapel HillNorth ^[6] CSL Behring, Med AffairsKing of Prussia,Pennsylvania ^[7] Haplogenics CorporationBrownsville,Texas ^[8] CSL Behring GmbH, ResearchMarburg,Germany ^[9] Hemostasis BranchU.S. Food and Drug AdministrationSilver Spring,Maryland ^[10] CSL Limited ResearchBio21 InstituteMelbourne,Australia ^[11]

关键词 blood coagulation factor inhibitors factor VIII hemophilia A histocompatibility antigens class II peptide quantitative peptidomics sequence analysis

发布时间 2020-06-03

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