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Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling

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第一作者： Partidos, Charalambos D.

作者： Partidos, Charalambos D. ^[1] ; Weger, James ^[2] ; Brewoo, Joseph ^[3] ; Seymour, Robert ^[4] ; Borland, Erin M. ^[5] ; Ledermann, Jeremy P. ; Powers, Ann M. ; Weaver, Scott C. ; Stinchcomb, Dan T. ; Osorio, Jorge E. .

作者单位： Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States ^[1] Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, United States ^[2] Sealy Center for Vaccine Development, Institute for Human Infections and Immunity and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, United States ^[3] Inviragen, Inc, Ft Collins, 1613 Prospect Parkway, Suite 100, Ft Collins, CO 80525, United States ^[4] Division of Vector-Borne Diseases, Centers for Disease Control, Ft Collins, CO 80521, United States ^[5]

关键词 interferon-gamma: IFN-gamma interleukin-12: IL-12 neutralizing antibody interferon-alpha-beta interferon: IFN signaling interferon-gamma receptor: signaling Chikungunya virus vaccine: immunologic-drug antiviral-drug immunostimulant-drug antiinfective-drug immunogenic potential Army Medical Research Institute of Infectious Diseases

发布时间 2013-11-20

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