Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
第一作者:
M,Elchebly
第一单位:
Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6.
作者:
医学主题词
动物(Animals);血糖(Blood Glucose);糖尿病, 2型(Diabetes Mellitus, Type 2);膳食脂肪类(Dietary Fats);基因打靶(Gene Targeting);葡糖耐量试验(Glucose Tolerance Test);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);胰岛素抗药性(Insulin Resistance);肝(Liver);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌, 骨骼(Muscle, Skeletal);肥胖症(Obesity);磷蛋白类(Phosphoproteins);磷酰化(Phosphorylation);磷酸酪氨酸(Phosphotyrosine);蛋白质酪氨酸磷酸酶类(Protein Tyrosine Phosphatases);受体, 胰岛素(Receptor, Insulin);信号传导(Signal Transduction)
DOI
10.1126/science.283.5407.1544
PMID
10066179
发布时间
2022-02-27
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