换一批Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate.
第一作者：
Q,Meng
第一单位：
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA.
作者：
医学主题词
细胞系(Cell Line);圆二色性(Circular Dichroism);胶原酶类(Collagenases);结晶学, X线(Crystallography, X-Ray);DNA引物(DNA Primers);明胶酶类(Gelatinases);动力学(Kinetics);基质金属蛋白酶1(Matrix Metalloproteinase 1);基质金属蛋白酶2(Matrix Metalloproteinase 2);基质金属蛋白酶3(Matrix Metalloproteinase 3);金属内肽酶类(Metalloendopeptidases);模型, 分子(Models, Molecular);分子结构(Molecular Structure);诱变, 定点(Mutagenesis, Site-Directed);蛋白质构象(Protein Conformation);蛋白质折叠(Protein Folding);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity);金属蛋白酶1组织抑制剂(Tissue Inhibitor of Metalloproteinase-1);增量调节(Up-Regulation)
DOI
10.1074/jbc.274.15.10184
PMID
10187802
发布时间
2022-02-23
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