The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53.
作者:
主题词
动物(Animals);碱基序列(Base Sequence);结合部位(Binding Sites);乳腺肿瘤(Breast Neoplasms);喜树碱(Camptothecin);催化作用(Catalysis);细胞系(Cell Line);DNA(DNA);DNA拓扑异构酶类, Ⅰ型(DNA Topoisomerases, Type I);女(雌)性(Female);动力学(Kinetics);丝裂霉素(Mitomycin);诱变, 定点(Mutagenesis, Site-Directed);寡脱氧核糖核苷酸类(Oligodeoxyribonucleotides);重组蛋白质类(Recombinant Proteins);序列缺失(Sequence Deletion);转录因子(Transcription Factors);转染(Transfection);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1073/pnas.96.18.10355
PMID
10468612
发布时间
2019-05-01
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