Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.
第一作者:
S,Han
第一单位:
Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea. shwhan@unitel.co.kr
作者:
医学主题词
成年人(Adult);老年人(Aged);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);乳腺肿瘤(Breast Neoplasms);癌, 导管, 乳腺(Carcinoma, Ductal, Breast);细胞周期(Cell Cycle);细胞周期蛋白质类(Cell Cycle Proteins);细胞分化(Cell Differentiation);细胞分裂(Cell Division);化学疗法, 辅助(Chemotherapy, Adjuvant);综合疗法(Combined Modality Therapy);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);环磷酰胺(Cyclophosphamide);无病生存(Disease-Free Survival);女(雌)性(Female);氟尿嘧啶(Fluorouracil);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);乳房切除术(Mastectomy);甲氨蝶呤(Methotrexate);微管相关蛋白质类(Microtubule-Associated Proteins);中年人(Middle Aged);肿瘤转移(Neoplasm Metastasis);肿瘤蛋白质类(Neoplasm Proteins);倍性(Ploidies);受体, 雌激素(Receptors, Estrogen);受体, 孕酮(Receptors, Progesterone);危险因素(Risk Factors);存活率分析(Survival Analysis);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1023/a:1006258222233
PMID
10481943
发布时间
2019-09-05
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