Cytotoxic necrotizing factor type 2 produced by pathogenic Escherichia coli deamidates a gln residue in the conserved G-3 domain of the rho family and preferentially inhibits the GTPase activity of RhoA and rac1.
作者:
主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);细菌毒素类(Bacterial Toxins);印迹法, 蛋白质(Blotting, Western);COS细胞(COS Cells);细胞毒素类(Cytotoxins);电泳, 聚丙烯酰氨凝胶(Electrophoresis, Polyacrylamide Gel);大肠杆菌(Escherichia coli);大肠杆菌蛋白质类(Escherichia coli Proteins);GTP磷酸水解酶类(GTP Phosphohydrolases);GTP酶激活蛋白质类(GTPase-Activating Proteins);分子序列数据(Molecular Sequence Data);重组蛋白质类(Recombinant Proteins);底物特异性(Substrate Specificity);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)
DOI
10.1128/IAI.67.12.6550-6557.1999
PMID
10569774
发布时间
2021-05-26
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Infection and immunity
6550-7页
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