The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.
第一作者:
C,McCormick
第一单位:
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
作者:
医学主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);碱基序列(Base Sequence);催化作用(Catalysis);牛(Cattle);细胞系(Cell Line);外生骨疣, 多发性遗传性(Exostoses, Multiple Hereditary);基因, 肿瘤抑制(Genes, Tumor Suppressor);糖基转移酶类(Glycosyltransferases);高尔基体(Golgi Apparatus);绿色荧光蛋白质类(Green Fluorescent Proteins);硫酸乙酰肝素(Heparitin Sulfate);人类(Humans);发光蛋白质类(Luminescent Proteins);大分子物质(Macromolecular Substances);小鼠(Mice);显微镜检查, 荧光(Microscopy, Fluorescence);分子序列数据(Molecular Sequence Data);突变(Mutation);N-乙酰氨基葡糖转移酶类(N-Acetylglucosaminyltransferases);蛋白质类(Proteins);重组融合蛋白质类(Recombinant Fusion Proteins)
DOI
10.1073/pnas.97.2.668
PMID
10639137
发布时间
2025-01-03
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