Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
作者:
主题词
7,8-二氢-7,8-二羟苯(a)并芘9,10-氧化物(7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide);动物(Animals);结合部位(Binding Sites);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);DNA加合物(DNA Adducts);DNA拓扑异构酶类, Ⅰ型(DNA Topoisomerases, Type I);人类(Humans);重组融合蛋白质类(Recombinant Fusion Proteins);重组, 遗传(Recombination, Genetic)
DOI
10.1073/pnas.040397497
PMID
10688881
发布时间
2023-03-31
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