换一批Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms.
第一作者：
F M,Sirotnak
第一单位：
Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. sirotnaf@mskcc.org
作者：
医学主题词
动物(Animals);碱基序列(Base Sequence);细胞系(Cell Line);仓鼠亚科(Cricetinae);DNA引物(DNA Primers);抗药性(Drug Resistance);基因表达(Gene Expression);动力学(Kinetics);蛋白质结合(Protein Binding);蛋白质亚型(Protein Isoforms);微管蛋白(Tubulin);长春花生物碱类(Vinca Alkaloids);长春新碱(Vincristine)
DOI
10.1006/bbrc.2000.2246
PMID
10694470
发布时间
2015-11-19
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