Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo.
第一作者:
C L,Chernicky
第一单位:
Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
作者:
医学主题词
成年人(Adult);动物(Animals);抗肿瘤药(Antineoplastic Agents);乳腺肿瘤(Breast Neoplasms);癌, 导管, 乳腺(Carcinoma, Ductal, Breast);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);RNA, 反义(RNA, Antisense);受体, IGF1型(Receptor, IGF Type 1);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1038/sj.cgt.7700126
PMID
10766344
发布时间
2009-11-19
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Cancer gene therapy
384-95页
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