换一批
换一批Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors.
第一作者：
H,Pelemans
第一单位：
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
作者：
主题词
酰苯胺类(Anilides);抗HIV药(Anti-HIV Agents);DNA突变分析(DNA Mutational Analysis);脱氧鸟嘌呤核苷酸类(Deoxyguanine Nucleotides);双脱氧核苷酸类(Dideoxynucleotides);药物设计(Drug Design);呋喃类(Furans);HIV逆转录酶(HIV Reverse Transcriptase);人类(Humans);诱变, 定点(Mutagenesis, Site-Directed);重组蛋白质类(Recombinant Proteins);逆转录酶抑制剂(Reverse Transcriptase Inhibitors);构效关系(Structure-Activity Relationship);硫代酰胺类(Thioamides);色氨酸(Tryptophan);肿瘤细胞, 培养的(Tumor Cells, Cultured)
PMID
10779379
发布时间
2020-12-08
- 浏览1
Molecular pharmacology
954-60页
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