Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.
第一作者:
N,Kienzle
第一单位:
EBV Unit, The Queensland Institute of Medical Research and University of Queensland Joint Oncology Program, Brisbane, Queensland, Australia. nobertK@qimr.edu.au
作者:
医学主题词
选择性剪接(Alternative Splicing);抗原呈递(Antigen Presentation);抗原呈递细胞(Antigen-Presenting Cells);细胞系, 转化(Cell Line, Transformed);细胞毒性试验, 免疫(Cytotoxicity Tests, Immunologic);细胞毒性, 免疫(Cytotoxicity, Immunologic);剂量效应关系, 免疫(Dose-Response Relationship, Immunologic);表位, T淋巴细胞(Epitopes, T-Lymphocyte);爱泼斯坦巴尔病毒核抗原(Epstein-Barr Virus Nuclear Antigens);遗传载体(Genetic Vectors);人类(Humans);免疫显性表位(Immunodominant Epitopes);免疫记忆(Immunologic Memory);淋巴细胞活化(Lymphocyte Activation);寡肽类(Oligopeptides);RNA, 病毒(RNA, Viral);受体, 抗原, T细胞, α-β(Receptors, Antigen, T-Cell, alpha-beta);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic)
DOI
10.4049/jimmunol.165.4.1840
PMID
10925262
发布时间
2019-05-15
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