Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures.
第一作者:
D,Oh
第一单位:
Department of Chemistry, Konkuk University, Seoul 143-701, Korea.
作者:
医学主题词
氨基酸序列(Amino Acid Sequence);氨基酸取代(Amino Acid Substitution);动物(Animals);抗菌药(Anti-Bacterial Agents);抗微生物阳离子肽类(Antimicrobial Cationic Peptides);抗肿瘤药(Antineoplastic Agents);枯草芽孢杆菌(Bacillus subtilis);导电性(Electric Conductivity);大肠杆菌(Escherichia coli);人类(Humans);离子通道(Ion Channels);Jurkat细胞(Jurkat Cells);K562细胞(K562 Cells);脂双层(Lipid Bilayers);爪蟾抗菌肽类(Magainins);分子序列数据(Molecular Sequence Data);核磁共振, 生物分子(Nuclear Magnetic Resonance, Biomolecular);肽碎片(Peptide Fragments);蛋白质结构, 二级(Protein Structure, Secondary);蛋白质结构, 三级(Protein Structure, Tertiary);色氨酸(Tryptophan);爪蟾蛋白质类(Xenopus Proteins)
DOI
10.1021/bi000453g
PMID
11009597
发布时间
2019-06-13
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Biochemistry
11855-64页
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