换一批ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
第一作者：
E A,Kowaluk
第一单位：
Neurological and Urological Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-6123, USA.
作者：
医学主题词
腺苷激酶(Adenosine Kinase);投药, 口服(Administration, Oral);镇痛药, 非麻醉(Analgesics, Non-Narcotic);动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);糖尿病, 实验性(Diabetes Mellitus, Experimental);水肿(Edema);酶抑制剂(Enzyme Inhibitors);甲醛(Formaldehyde);血流动力学(Hemodynamics);痛觉过敏(Hyperalgesia);男(雄)性(Male);吗啉类(Morpholines);运动活动(Motor Activity);疼痛(Pain);嘧啶类(Pyrimidines);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 嘌呤能P1(Receptors, Purinergic P1);链脲菌素(Streptozocin)
PMID
11082454
发布时间
2022-03-09
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