Development of a (32)P-postlabeling method for the detection of 1,N(2)-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo.
第一作者:
M,Wacker
第一单位:
Department of Toxicology, University of Würzburg, Versbacher Strasse 9, D-97078 Würzburg, Germany.
作者:
主题词
成年人(Adult);醛类(Aldehydes);动物(Animals);放射自显影术(Autoradiography);脑(Brain);脑化学(Brain Chemistry);色谱法, 薄层(Chromatography, Thin Layer);结肠(Colon);交联试剂(Cross-Linking Reagents);DNA加合物(DNA Adducts);脱氧鸟苷(Deoxyguanosine);药物稳定性(Drug Stability);女(雌)性(Female);人类(Humans);同位素标记(Isotope Labeling);脂质过氧化作用(Lipid Peroxidation);核苷酸类(Nucleotides);磷放射性同位素(Phosphorus Radioisotopes);大鼠(Rats);大鼠, 近交F344(Rats, Inbred F344);参考标准(Reference Standards);敏感性与特异性(Sensitivity and Specificity);单链特异性DNA和RNA内切核酸酶类(Single-Strand Specific DNA and RNA Endonucleases)
DOI
10.1021/tx000058r
PMID
11087439
发布时间
2019-09-21
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