Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens. Possible role in CD8+ T cell-mediated, virus-induced autoimmune disease.
作者:
主题词
过继转移(Adoptive Transfer);氨基酸序列(Amino Acid Sequence);动物(Animals);抗原(Antigens);自身免疫疾病(Autoimmune Diseases);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞分裂(Cell Division);细胞系(Cell Line);色谱法, 高压液相(Chromatography, High Pressure Liquid);剂量效应关系, 药物(Dose-Response Relationship, Drug);表位(Epitopes);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);胰岛素(Insulin);干扰素γ(Interferon-gamma);主要组织相容性复合物(Major Histocompatibility Complex);质谱分析法(Mass Spectrometry);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);突变(Mutation);肽类(Peptides);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);大鼠(Rats);脾(Spleen);构效关系(Structure-Activity Relationship);时间因素(Time Factors);移植(Transplantation)
DOI
10.1074/jbc.M008864200
PMID
11278441
发布时间
2021-02-09
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The Journal of biological chemistry
19396-403页
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