换一批Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
第一作者：
M A,Chishti
第一单位：
Centre for Research in Neurodegenerative Diseases, the Department of Laboratory Medicine, Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
作者：
医学主题词
衰老(Aging);氨基酸取代(Amino Acid Substitution);淀粉样蛋白(Amyloid);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);淀粉样变性(Amyloidosis);动物(Animals);脑(Brain);认知障碍(Cognition Disorders);交叉, 遗传(Crosses, Genetic);女(雌)性(Female);人类(Humans);男(雄)性(Male);迷宫学习(Maze Learning);小鼠(Mice);小鼠, 近交C3H(Mice, Inbred C3H);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);诱变, 定点(Mutagenesis, Site-Directed);启动区, 遗传(Promoter Regions, Genetic);限制性内切酶图谱法(Restriction Mapping)
DOI
10.1074/jbc.M100710200
PMID
11279122
发布时间
2022-03-09
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