换一批CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.
第一作者：
D,Bozyczko-Coyne
第一单位：
Cephalon Inc., West Chester, Pennsylvania 19380, USA. dbozyck@cephalon.com
作者：
医学主题词
淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);细胞凋亡(Apoptosis);卡配因(Calpain);卡唑类(Carbazoles);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);细胞色素c组(Cytochrome c Group);细胞质(Cytoplasm);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);基因表达(Gene Expression);吲哚类(Indoles);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);L-乳酸脱氢酶(L-Lactate Dehydrogenase);MAP激酶激酶4(MAP Kinase Kinase 4);丝裂原激活蛋白激酶激酶类(Mitogen-Activated Protein Kinase Kinases);神经元(Neurons);妊娠(Pregnancy);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)
DOI
10.1046/j.1471-4159.2001.00294.x
PMID
11331414
发布时间
2019-06-30
- 浏览10
Journal of neurochemistry
849-63页
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