A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
第一作者:
S,Neumann
第一单位:
Third Medical Department, University of Leipzig, D-04103 Leipzig, Germany.
作者:
医学主题词
动物(Animals);天冬氨酸(Aspartic Acid);结合, 竞争性(Binding, Competitive);COS细胞(COS Cells);化学现象(Chemical Phenomena);化学, 物理(Chemistry, Physical);计算机模拟(Computer Simulation);环AMP(Cyclic AMP);流式细胞术(Flow Cytometry);GTP结合蛋白质类(GTP-Binding Proteins);人类(Humans);氢键合(Hydrogen Bonding);肌醇磷酸类(Inositol Phosphates);模型, 分子(Models, Molecular);诱变, 定点(Mutagenesis, Site-Directed);氧(Oxygen);聚合酶链反应(Polymerase Chain Reaction);受体, 促甲状腺素(Receptors, Thyrotropin);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);促甲状腺素(Thyrotropin);转染(Transfection)
DOI
10.1210/mend.15.8.0672
PMID
11463854
发布时间
2016-11-24
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