换一批Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.
第一作者：
M,Raida
第一单位：
Department of Internal Medicine II, Friedrich-Schiller-Universität Jena, D-07740 Jena, Germany. m.raida@icrf.icnet.uk
作者：
医学主题词
成年人(Adult);老年人(Aged);选择性剪接(Alternative Splicing);抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);乳腺肿瘤(Breast Neoplasms);结肠肿瘤(Colonic Neoplasms);DNA, 互补(DNA, Complementary);腹泻(Diarrhea);二氢尿嘧啶脱氢酶(NADP)(Dihydrouracil Dehydrogenase (NADP));外显子(Exons);女(雌)性(Female);氟尿嘧啶(Fluorouracil);基因频率(Gene Frequency);基因型(Genotype);杂合子(Heterozygote);纯合子(Homozygote);人类(Humans);内含子(Introns);白细胞减少(Leukopenia);男(雄)性(Male);中年人(Middle Aged);氧化还原酶类(Oxidoreductases);点突变(Point Mutation);直肠肿瘤(Rectal Neoplasms);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);疾病严重程度指数(Severity of Illness Index);胃肿瘤(Stomach Neoplasms);口炎(Stomatitis);血小板减少(Thrombocytopenia)
PMID
11555601
发布时间
2022-03-21
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Clinical cancer research
2832-9页
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