Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU.
第一作者:
T C,Maleniak
第一单位:
Molecular Medicine and Gene Therapy Unit, School of Medicine, University of Manchester, Manchester M13 9PT, UK.
作者:
主题词
腺病毒科(Adenoviridae);抗肿瘤药, 烷基化(Antineoplastic Agents, Alkylating);细胞凋亡(Apoptosis);脑肿瘤(Brain Neoplasms);综合疗法(Combined Modality Therapy);DNA, 重组(DNA, Recombinant);抗药性, 肿瘤(Drug Resistance, Neoplasm);Fas配体蛋白质(Fas Ligand Protein);半乳糖苷类(Galactosides);更昔洛韦(Ganciclovir);基因表达(Gene Expression);遗传载体(Genetic Vectors);胶质母细胞瘤(Glioblastoma);疱疹病毒1型, 人(Herpesvirus 1, Human);人类(Humans);吲哚类(Indoles);洛莫司汀(Lomustine);膜糖蛋白类(Membrane Glycoproteins);胸苷激酶(Thymidine Kinase);肿瘤细胞, 培养的(Tumor Cells, Cultured);β半乳糖苷酶类(beta-Galactosidase)
DOI
10.1038/sj.cgt.7700348
PMID
11571537
发布时间
2013-11-21
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Cancer gene therapy
589-98页
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