Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice.
第一作者:
M A,Taylor
第一单位:
Graduate Program in Immunology, and Departments of Pathology, and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. mesha.taylor@utsouthwestern.edu
作者:
医学主题词
动物(Animals);细胞凋亡(Apoptosis);骨髓移植(Bone Marrow Transplantation);CASP8和FADD样细胞凋亡调节蛋白质(CASP8 and FADD-Like Apoptosis Regulating Protein);载体蛋白质类(Carrier Proteins);基因, MHCⅠ类(Genes, MHC Class I);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);Jurkat细胞(Jurkat Cells);杀伤细胞, 天然(Killer Cells, Natural);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);小鼠, 突变型(Mice, Mutant Strains);肿瘤移植(Neoplasm Transplantation);穿孔素(Perforin);成孔毒素蛋白质类(Pore Forming Cytotoxic Proteins);受体, 肿瘤坏死因子(Receptors, Tumor Necrosis Factor);信号传导(Signal Transduction);移植免疫学(Transplantation Immunology)
DOI
10.4049/jimmunol.167.8.4230
PMID
11591744
发布时间
2019-05-15
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