换一批Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5'-sulfonamide moiety of a phenyl ring.
第一作者：
D K,Kim
第一单位：
Life Science Research Center, SK Chemicals, 600 Jungja-Dong, Changan-Ku, Suwon-Si, 440-745, Kyungki-Do, South Korea. dkkim@skchemicals.com
作者：
医学主题词
3',5'-环GMP磷酸二酯酶类(3',5'-Cyclic-GMP Phosphodiesterases);动物(Animals);羧酸类(Carboxylic Acids);牛(Cattle);环核苷酸磷酸二酯酶类, 5型(Cyclic Nucleotide Phosphodiesterases, Type 5);药物评价, 临床前(Drug Evaluation, Preclinical);勃起功能障碍(Erectile Dysfunction);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);同工酶类(Isoenzymes);男(雄)性(Male);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);哌嗪类(Piperazines);嘌呤类(Purines);兔(Rabbits);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides);砜类(Sulfones)
DOI
10.1016/s0968-0896(01)00200-0
PMID
11597484
发布时间
2019-09-01
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