Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.
第一作者:
Claus,Schneider
第一单位:
Department of Pharmacology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
作者:
医学主题词
动物(Animals);环氧化酶1(Cyclooxygenase 1);环氧化酶2(Cyclooxygenase 2);人类(Humans);羟基花生四烯酸类(Hydroxyeicosatetraenoic Acids);同工酶类(Isoenzymes);膜蛋白质类(Membrane Proteins);小鼠(Mice);分子构象(Molecular Conformation);诱变, 定点(Mutagenesis, Site-Directed);前列腺素内过氧化物合酶类(Prostaglandin-Endoperoxide Synthases);前列腺素(Prostaglandins);丝氨酸(Serine)
DOI
10.1074/jbc.M107471200
PMID
11677234
发布时间
2021-02-09
基金项目
CA89450/CA/NCI NIH HHS/United States
GM-53638/GM/NIGMS NIH HHS/United States
TW-00404/TW/FIC NIH HHS/United States
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