Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells.
第一作者:
James A L,Fenton
第一单位:
Department of Pathology, Leiden University Medical Center, The Netherland.
作者:
医学主题词
老年人(Aged);B-淋巴细胞(B-Lymphocytes);碱基序列(Base Sequence);细胞分化(Cell Differentiation);染色体断裂(Chromosome Breakage);染色体, 人, 14对(Chromosomes, Human, Pair 14);染色体, 人, 16对(Chromosomes, Human, Pair 16);DNA, 肿瘤(DNA, Neoplasm);胚胎性癌干细胞(Embryonal Carcinoma Stem Cells);女(雌)性(Female);基因, 免疫球蛋白(Genes, Immunoglobulin);基因, 开关(Genes, Switch);基因, bcl-2(Genes, bcl-2);生发中心(Germinal Center);人类(Humans);免疫球蛋白重链(Immunoglobulin Heavy Chains);淋巴瘤, 滤泡性(Lymphoma, Follicular);分子序列数据(Molecular Sequence Data);肿瘤干细胞(Neoplastic Stem Cells);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);RNA, 信使(RNA, Messenger);RNA, 肿瘤(RNA, Neoplasm);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);体细胞高突变, 免疫球蛋白(Somatic Hypermutation, Immunoglobulin);易位, 遗传(Translocation, Genetic)
DOI
10.1182/blood.v99.2.716
PMID
11781262
发布时间
2021-02-16
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Blood
716-8页
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