Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.
第一作者:
Ciaran,Sewter
第一单位:
Department of Clinical Biochemistry and Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
作者:
主题词
脂细胞(Adipocytes);成年人(Adult);CCAAT增强子结合蛋白类(CCAAT-Enhancer-Binding Proteins);DNA结合蛋白质类(DNA-Binding Proteins);糖尿病(Diabetes Mellitus);糖尿病, 2型(Diabetes Mellitus, Type 2);女(雌)性(Female);基因表达调控(Gene Expression Regulation);人类(Humans);男(雄)性(Male);肥胖症(Obesity);肥胖症, 病态(Obesity, Morbid);蛋白质亚型(Protein Isoforms);RNA, 信使(RNA, Messenger);参考值(Reference Values);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.2337/diabetes.51.4.1035
PMID
11916923
发布时间
2019-05-15
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Diabetes
1035-41页
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