Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.

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作者： Stanley,Cohen ^[1] ; Eric,Hurd ; John,Cush ; Michael,Schiff ; Michael E,Weinblatt ; Larry W,Moreland ; Joel,Kremer ; Moraye B,Bear ; William J,Rich ; Dorothy,McCabe

作者单位： Department of Rheumatology, St. Paul Medical Center, Dallas, Texas 75235, USA. stanleycohen@radiantresearch.com ^[1]

主题词抗体(Antibodies);抗风湿药(Antirheumatic Agents);关节炎, 类风湿(Arthritis, Rheumatoid);血沉(Blood Sedimentation);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);药物疗法, 联合(Drug Therapy, Combination);女(雌)性(Female);人类(Humans);白细胞介素1受体拮抗蛋白质(Interleukin 1 Receptor Antagonist Protein);男(雄)性(Male);甲氨蝶呤(Methotrexate);中年人(Middle Aged);重组蛋白质类(Recombinant Proteins);安全(Safety);疾病严重程度指数(Severity of Illness Index);唾液糖蛋白类(Sialoglycoproteins);治疗结果(Treatment Outcome)

DOI 10.1002/art.10141

PMID 11920396

发布时间 2022-04-08

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Arthritis and rheumatism

2002年46卷3期

614-24页

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Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.

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Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.

Arthritis and rheumatism

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Arthritis and rheumatism

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