Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides.
第一作者:
Yan,Chen
第一单位:
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
作者:
主题词
细胞系(Cell Line);内皮, 血管(Endothelium, Vascular);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);胞间黏附分子1(Intercellular Adhesion Molecule-1);分子构象(Molecular Conformation);诱变(Mutagenesis);肽类, 环(Peptides, Cyclic);构效关系(Structure-Activity Relationship);血管细胞黏附分子1(Vascular Cell Adhesion Molecule-1)
DOI
10.1021/ja020166v
PMID
11996584
发布时间
2019-07-08
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