换一批
换一批Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity.
作者：
主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);喜树碱(Camptothecin);羧酸酯酶(Carboxylesterase);羧酸酯水解酶类(Carboxylic Ester Hydrolases);人类(Humans);水解作用(Hydrolysis);肾(Kidney);脂肪酶(Lipase);肝(Liver);小鼠(Mice);分子序列数据(Molecular Sequence Data);肽碎片(Peptide Fragments);药物前体(Prodrugs);序列同源性, 氨基酸(Sequence Homology, Amino Acid);底物特异性(Substrate Specificity)
DOI
10.1124/dmd.31.1.21
PMID
12485949
发布时间
2025-02-12
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