换一批
换一批The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
第一作者：
Rommel G,Tirona
第一单位：
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
作者：
主题词
动物(Animals);碱基序列(Base Sequence);碱性螺旋-环-螺旋亮氨酸拉链转录因子类(Basic Helix-Loop-Helix Leucine Zipper Transcription Factors);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA引物(DNA Primers);DNA结合蛋白质类(DNA-Binding Proteins);电泳迁移位移试验(Electrophoretic Mobility Shift Assay);增强子元件, 遗传学(Enhancer Elements, Genetic);酶诱导(Enzyme Induction);肝细胞核因子4(Hepatocyte Nuclear Factor 4);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷蛋白类(Phosphoproteins);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);受体, 类固醇(Receptors, Steroid);转录因子(Transcription Factors);肿瘤细胞, 培养的(Tumor Cells, Cultured);异生物质(Xenobiotics)
DOI
10.1038/nm815
PMID
12514743
发布时间
2021-12-03
- 浏览74
Nature medicine
220-4页
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