Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase.
第一作者:
Anthony C,Bishop
第一单位:
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, BCC379, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
作者:
主题词
生物转运(Biological Transport);催化作用(Catalysis);脱氧腺嘌呤核苷酸类(Deoxyadenine Nucleotides);异亮氨酸tRNA连接酶(Isoleucine-tRNA Ligase);突变(Mutation);蛋白质构象(Protein Conformation);RNA编辑(RNA Editing);RNA, 转移, 异亮氨酸(RNA, Transfer, Ile);缬氨酸(Valine);缬氨酸tRNA连接酶(Valine-tRNA Ligase)
DOI
10.1073/pnas.0237335100
PMID
12515858
发布时间
2023-11-05
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